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Chem. 241, 5201. Fatty Acid Biosynthesis 31 Alberts, A. , and Vagelos, P. R. (1963). /. Biol. Chem. 238, 557. Alberts, A. , Majerus, P. , and Vagelos, P. R. (1964). Biochemistry 3, 1563. Alberts, A. , Majerus, P. , and Vagelos, P. R. (1965). Biochemistry 4, 2265. Allmann, D. , Hubbard, D. , and Gibson, D. M. (1965). /. Lipid Res. 6, 63. Andreasen, A. , and Stier, T. J. B. (1954). J. Cellular Comp. Physiol. 43, 271. , and Thain, E. M. (1951). J. Chem. Soc. 246, 2253. Bloomfield, D. , and Bloch, K.
The historic landmarks in the experimental development of this subject have been: demonstration that hormonal stimuli are capable of causing an acute mobilization of stored lipid (Best and Campbell, 1936); demonstration that stored triglycéride undergoes constant metabolic turnover (Schoenheimer and Rittenberg, 1936); introduction of in vitro techniques for observing the metabolic activities and hormonal responses of adipose tissue (Shapiro and Wertheimer, 1948; White and Engel, 1958a; Gordon and Cherkes, 1958; Winegrad and Renold, 1958a,b; Scow et al, 1962; Rodbell, 1964); demonstration that circulating free fatty acids (FFA) represent the form in which stored triglycéride is mobilized (Gordon and Cherkes, 1956; Dole, 1956; Laurell, 1956); use of C14-labeled substrates in vitro for quantitative study of the interdigitating metabolic pathways for glucose and fatty acid metabolism within the fat cell (Flatt and Ball, 1964, Laudau and Katz, 1964); investigations, still in an early stage, of the enzymes involved in the intermediary metabolism of the fat cell and in its hormonal responses (Korn and Quigley, 1957; Rizack, 1961; Vaughan et al, 1964a; Klainer et al, 1962; Martin et al, 1961).
1967). / . Biol. Chem. 242 (in press). Majerus, P. , and Vagelos, P. R. (1964). Federation Proc. 23, 166. Majerus, P. , Alberts, A. , and Vagelos, P. R. (1964). Proc. Natl. Acad. Sei. S. 51, 1231. Majerus, P. , Alberts, A. , and Vagelos, P. R. (1965a). Proc. Natl. Acad. Set. S. 53, 410. Majerus, P. , Alberts, A. , and Vagelos, P. R. (1965b). / . Biol. Chem. 240, 618. Majerus, P. , Alberts, A. , and Vagelos, P. R. (1965c). / . Biol. Chem. 240, 4723. Majerus, P. , Alberts, A. , and Vagelos, P. R.