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The integrity of this factor structure is not disrupted in ASC, but the activity of brain regions within such an unit alters with psychedelic states. The "fronto-parietal factor" appears to play a fundamental role as a "central supervision and execution system" insofar as this unit is involved in ego-structuring processes and self-representation by interpretation and integration of extra- and intrasensory information, planning and execution of motor functions. The hyperfrontality hypothesis of ketamine- and psilocybin-induced mental states has been tested in healthy volunteers using positron emission tomography (PET) and the radioligand [18F]fluorodeoxyglucose (FDG).

207242. Meltzer HY. (1991): The mechanism of action of novel antipsychotic drugs. Schizophrenia Bull 17:263-287 Meltzer HY, Gudelsky GA. (1992): Dopaminergic and serotonergic effects of clozapine -Implications for a unique profile. Arzneim Forsch 42:268-272 Padich RA, McCloskey TC, Kehne JH. (1996): 5-HT modulation of auditory and visual sensorimotor gating:II. effects of the 5-HT2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats.

Current status and perspectives of hallucinogens. 101-118. Fischman LG. (1983): Dreams, hallucinogenic drug states, and schizophrenia: a psychological and 30 The Heffter Review of Psychedelic Research, Volume 1, 1998 sensorimotor gating in the rat. Neuropsychopharm 2:299-308 Meert TF, de Haes P, Janssen PA. (1989): Risperidone (R 64 766), a potent and complete LSD antagonist in drug discrimination by rats. Psychopharmacology (Berlin) 97:206-212 Meltzer HY, Fessler RG, Simonovic M, Fang VS. (1978): Stimulation of rat prolactin secretion by indolealkylamine hallucinogens.

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